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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4increases expressionISOATF4 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of ATF4 proteinPMID:29266867
Atf4increases expressionISOAtf4 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of ATF4 mRNA; Arsenic Trioxide results in increased expression of ATF4 proteinPMID:23892647 PMID:27638049
Atf4multiple interactionsISOATF4 (Homo sapiens)6480464CTDDasatinib inhibits the reaction [Arsenic Trioxide results in increased expression of ATF4 protein]PMID:29266867
Atf4multiple interactionsISOAtf4 (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of ATF4 protein]; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of ATF4 protein]; [Arsenic Trioxide results in increased abundance of Reactive Oxygen Species] which results in increased expression of ATF4 protein; Arsenic Trioxide results in increased expression of and affects the localization of ATF4 protein; ATF4 protein affects the reaction [Arsenic Trioxide results in decreased expression of IL1B mRNA]; ATF4 protein affects the reaction [Arsenic Trioxide results in decreased expression of ITGAM protein]; ATF4 protein affects the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; ATF4 protein affects the reaction [Arsenic Trioxide results in increased expression of IL10 mRNA]; ATF4 protein affects the reaction [Arsenic Trioxide results in increased expression of TGFB1 mRNA]; ATF4 protein affects the reaction [Arsenic Trioxide results in increased expression of TNF mRNA]; ATF4 protein promotes the reaction [Arsenic Trioxide affects the expression of DNM1L protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of and affects the localization of BAX protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of and affects the localization of CYCS protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of and affects the localization of RAC1 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of CAPN1 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of CASP12 protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of DDIT3 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of EIF2AK3 protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSP90B1 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA5 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of HSPA9 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of ITPR1 protein modified form]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of NCF1 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased expression of NCF2 protein]; ATF4 protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of TP53 protein]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of ATF4 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of ATF4 protein]PMID:23892647 PMID:27461142 PMID:27638049
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