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Gene: ATF4 (activating transcription factor 4) Homo sapiens
Symbol: ATF4
Name: activating transcription factor 4
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription factor binding activity; and leucine zipper domain binding activity. Involved in several processes, including L-asparagine metabolic process; negative regulation of oxidative stress-induced neuron death; and positive regulation of gene expression. Localizes to several cellular components, including CHOP-ATF4 complex; Lewy body core; and nucleus. Colocalizes with centrosome. Implicated in prostate carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: activating transcription factor atf-4; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB-2; CREB2; cyclic AMP-dependent transcription factor ATF-4; cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; tax-responsive enhancer element B67; tax-responsive enhancer element-binding protein 67; TAXREB67; TXREB
Mus musculus (house mouse) : Atf4 (activating transcription factor 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atf4 (activating transcription factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atf4 (activating transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ATF4 (activating transcription factor 4)
Canis lupus familiaris (dog) : ATF4 (activating transcription factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atf4 (activating transcription factor 4)
Sus scrofa (pig) : ATF4 (activating transcription factor 4)
Chlorocebus sabaeus (African green monkey) : ATF4 (activating transcription factor 4)
Heterocephalus glaber (naked mole-rat) : Atf4 (activating transcription factor 4)
more info ...
Related Pseudogenes: ATF4P1   ATF4P2   ATF4P3   ATF4P4  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2239,519,695 - 39,522,685 (+)EnsemblGRCh38hg38GRCh38
GRCh382239,514,494 - 39,522,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372239,916,569 - 39,918,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,246,515 - 38,248,637 (+)NCBINCBI36hg18NCBI36
Build 342238,241,068 - 38,243,191NCBI
Celera2223,718,625 - 23,720,747 (+)NCBI
Cytogenetic Map22q13.1NCBI
HuRef2222,881,158 - 22,883,280 (+)NCBIHuRef
CHM1_12239,875,303 - 39,877,431 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ATF4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733712
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-08-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.