Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	621863
Species:	Rattus norvegicus
RGD Object:	Gene
Symbol:	Atf4
Name:	activating transcription factor 4

Acc ID:	CHEBI:28939
Term:	N-acetyl-L-cysteine
Definition:	An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.
Chemical ID:	MESH:D000111

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Atf4	decreases expression	EXP		6480464	CTD	Acetylcysteine results in decreased expression of ATF4 protein	PMID:27484784
Atf4	multiple interactions	EXP		6480464	CTD	[Acetylcysteine co-treated with Trichloroethylene] results in increased expression of ATF4 mRNA; Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]	PMID:24291486 PMID:27484784 PMID:36396003
Atf4	increases expression	ISO	ATF4 (Homo sapiens)	6480464	CTD	Acetylcysteine results in increased expression of ATF4 protein	PMID:19722195
Atf4	multiple interactions	ISO	ATF4 (Homo sapiens)	6480464	CTD	Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [bisphenol A results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [bisphenol S results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [scutebarbatine A results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]	PMID:15788408 PMID:21266191 PMID:25568320 PMID:27634458 PMID:27816613 PMID:28754437 PMID:32506763 PMID:37072049 PMID:37300854 PMID:37944787
Atf4	multiple interactions	ISO	Atf4 (Mus musculus)	6480464	CTD	Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of ATF4 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]	PMID:25451595 PMID:31330229 PMID:32578922

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