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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621812
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3increases expressionEXP 6480464CTDbisphenol A results in increased expression of CXCL3 mRNAPMID:25181051
Cxcl3affects expressionISOCxcl3 (Mus musculus)6480464CTDbisphenol A affects the expression of CXCL3 mRNAPMID:27082013
Cxcl3decreases expressionISOCXCL1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of CXCL1 mRNAPMID:27685785
Cxcl3decreases expressionISOCxcl3 (Mus musculus)6480464CTDbisphenol A results in decreased expression of CXCL1 mRNAPMID:32156529
Cxcl3increases expressionISOCXCL1 (Homo sapiens)6480464CTDbisphenol A results in increased expression of CXCL1 mRNAPMID:38568856
Cxcl3multiple interactionsISOCxcl3 (Mus musculus)6480464CTD[bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of CXCL1 mRNA; [Ovalbumin co-treated with bisphenol A] results in increased expression of and results in increased secretion of CXCL1 protein; [XRCC6 gene mutant form results in increased susceptibility to potassium bromate] affects the reaction [bisphenol A affects the expression of CXCL3 mRNA]; bisphenol A promotes the reaction [OVAL protein results in increased secretion of CXCL1 protein]PMID:27082013 PMID:27087817 PMID:29737898 PMID:35739755
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