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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621731
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ddit4
Name: DNA-damage-inducible transcript 4
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit4increases expressionEXP 6480464CTDDexamethasone results in increased expression of DDIT4 mRNA; Dexamethasone results in increased expression of DDIT4 proteinPMID:20032058
Ddit4multiple interactionsEXP 6480464CTD[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]; bicalutamide inhibits the reaction [[Testosterone binds to AR protein] inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]; Testosterone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 mRNA]; Testosterone inhibits the reaction [Dexamethasone results in increased expression of DDIT4 protein]PMID:20032058
Ddit4decreases expressionISODDIT4 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of DDIT4 mRNAPMID:25047013
Ddit4increases expressionISODdit4 (Mus musculus)6480464CTDDexamethasone results in increased expression of DDIT4; Dexamethasone results in increased expression of DDIT4 mRNAPMID:17998272 PMID:22733784 PMID:22936724
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