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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:64163
Term: diquat
Definition: The organic cation formed formally by addition of an ethylene bridge between the nitrogen atoms of 2,2'-bipyridine. Most often available as the dibromide.
Chemical ID: MESH:D004178
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityISOGpt (Mus musculus)6480464CTDDiquat results in increased activity of GPT proteinPMID:15496407 PMID:35268077
Gptincreases expressionISOGpt (Mus musculus)6480464CTDDiquat results in increased expression of GPT mRNA; Diquat results in increased expression of GPT proteinPMID:33475796 PMID:36851058
Gptmultiple interactionsISOGPT (Homo sapiens)6480464CTDGPX4 protein inhibits the reaction [Diquat results in increased activity of GPT protein]PMID:15496407
Gptmultiple interactionsISOGpt (Mus musculus)6480464CTDAscorbic Acid inhibits the reaction [Diquat results in increased expression of GPT protein]; Ellagic Acid inhibits the reaction [Diquat results in increased activity of GPT protein]PMID:33475796 PMID:35268077
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