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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621720
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpt
Name: glutamic--pyruvic transaminase
Acc ID: CHEBI:5063
Term: fipronil
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fipronil.
Chemical ID: MESH:C082360
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gptincreases activityEXP 6480464CTDfipronil results in increased activity of GPT proteinPMID:32651782
Gptmultiple interactionsEXP 6480464CTDPlant Extracts inhibits the reaction [fipronil results in increased activity of GPT protein]PMID:32651782
Gptincreases expressionISOGpt (Mus musculus)6480464CTDfipronil results in increased expression of GPT proteinPMID:25721553
Gptmultiple interactionsISOGPT (Homo sapiens)6480464CTD[imidacloprid co-treated with fipronil co-treated with Glyphosate] results in increased activity of and results in increased secretion of GPT protein; fipronil results in increased activity of and results in increased secretion of GPT proteinPMID:35850439
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