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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621675
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
Acc ID: CHEBI:46557
Term: zoledronic acid
Definition: An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
Chemical ID: MESH:C088658
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionISOTIMP1 (Homo sapiens)6480464CTDzoledronic acid results in increased expression of TIMP1 mRNA; zoledronic acid results in increased expression of TIMP1 proteinPMID:28871336
Timp1increases expressionISOTimp1 (Mus musculus)6480464CTDzoledronic acid results in increased expression of TIMP1 mRNAPMID:28871336
Timp1multiple interactionsISOTimp1 (Mus musculus)6480464CTDFenofibrate inhibits the reaction [zoledronic acid results in increased expression of TIMP1 mRNA]; SLC27A2 gene mutant form inhibits the reaction [zoledronic acid results in increased expression of TIMP1 mRNA]PMID:28871336
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