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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621675
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
Acc ID: CHEBI:113532
Term: thymoquinone
Definition: A member of the class of 1,4-benzoquinones that is 1,4-bezoquinone in which the hydrogens at positions 2 and 5 are replaced by methyl and isopropyl groups, respectively. It is a natural compound isolated from Nigella sativa which has demonstrated promising chemotherapeutic activity.
Chemical ID: MESH:C003466
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp1increases expressionISOTIMP1 (Homo sapiens)6480464CTDthymoquinone results in increased expression of TIMP1 proteinPMID:27060453
Timp1multiple interactionsISOTIMP1 (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; SB 203580 inhibits the reaction [thymoquinone results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [Lipopolysaccharides results in increased expression of TIMP1 protein]; thymoquinone inhibits the reaction [TGFB1 protein results in increased expression of TIMP1 protein]PMID:27060453 PMID:27688165 PMID:31935363
Timp1multiple interactionsISOTimp1 (Mus musculus)6480464CTDthymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA]; thymoquinone inhibits the reaction [Thioacetamide results in increased expression of TIMP1 protein]PMID:31935363
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