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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621619
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Keap1decreases expressionISOKEAP1 (Homo sapiens)6480464CTDVitamin K 3 results in decreased expression of KEAP1 mRNAPMID:23410634
Keap1multiple interactionsISOKEAP1 (Homo sapiens)6480464CTD[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in decreased susceptibility to Vitamin K 3PMID:19608619
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