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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621595
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vcp
Name: valosin-containing protein
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vcpmultiple interactionsISOVCP (Homo sapiens)6480464CTDSirolimus inhibits the reaction [VCP protein mutant form results in increased expression of SQSTM1 protein]PMID:25884947
Vcpmultiple interactionsISOVcp (Mus musculus)6480464CTDSirolimus inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of MTOR protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of RPS6KB1 protein modified form]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [VCP protein mutant form results in increased expression of TARDBP protein]PMID:25884947
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