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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:9352
Term: sulindac
Definition: A monocarboxylic acid that is 1-benzylidene-1H-indene which is substituted at positions 2, 3, and 5 by methyl, carboxymethyl, and fluorine respectively, and in which the phenyl group of the benzylidene moiety is substituted at the para position by a methylsulfinyl group. It is a prodrug for the corresponding sulfide, a non-steroidal anti-inflammatory drug, used particularly in the treatment of acute and chronic inflammatory conditions.
Chemical ID: MESH:D013467
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases expressionISOMapk8 (Mus musculus)6480464CTDSulindac results in increased expression of MAPK8 mRNAPMID:17292881
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDSulindac results in increased phosphorylation of MAPK8 proteinPMID:17292881
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDCDKN1A protein promotes the reaction [Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein]; MAPK8 affects the reaction [[Sulindac co-treated with Arsenic Trioxide] results in increased phosphorylation of BCL2L1 protein]; Sulindac promotes the reaction [IL24 protein results in increased phosphorylation of MAPK8 protein]; Sulindac results in increased expression of and results in increased phosphorylation of MAPK8 protein; Sulindac results in increased phosphorylation of and results in increased activity of MAPK8 proteinPMID:15713900 PMID:17292881 PMID:18281123
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