GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | multiple interactions | EXP | | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK8 mRNA; [sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK8 protein; Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK8 protein; Arsenic results in increased phosphorylation of and results in increased activity of MAPK8 protein; O(2)-(2,4-dinitrophenyl) 1-((4-ethoxycarbonyl)piperazin-1-yl)diazen-1-ium-1,2-diolate promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK8 protein]; O(2)-(2,4-dinitrophenyl) 1-(4-(N,N-diethylcarboxamido)piperazin-1-yl)diazen-1-ium 1,2-diolate promotes the reaction [Arsenic results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Ro 31-8220 inhibits the reaction [Arsenic results in decreased phosphorylation of and results in decreased activity of MAPK8 protein]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of MAPK8 mRNA] | PMID:11756236 PMID:15210857 PMID:35307918 PMID:36822304 | Mapk8 | increases phosphorylation | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Arsenic results in increased phosphorylation of MAPK8 protein | PMID:35031324 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | Arsenic results in increased phosphorylation of and results in increased activity of MAPK8 protein; MAPK8 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of ATF3 protein] | PMID:14633691 PMID:33921748 | Mapk8 | multiple interactions | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; [sodium arsenite results in increased abundance of Arsenic] which results in decreased phosphorylation of MAPK8 protein; Arsenic results in increased expression of and results in increased phosphorylation of MAPK8 protein; SPD-304 inhibits the reaction [Arsenic results in increased expression of and results in increased phosphorylation of MAPK8 protein] | PMID:33049506 PMID:39098089 | | ||||||||||||||||||||||
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