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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:34107
Term: 1-nitropyrene
Definition: A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion, it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine.
Chemical ID: MESH:C032668
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTD1-nitropyrene results in increased phosphorylation of MAPK8 proteinPMID:37993079
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTD1-nitropyrene results in increased phosphorylation of MAPK8 proteinPMID:17240030
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