Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621506
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk8affects methylationISOMAPK8 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of MAPK8 promoterPMID:27901495
Mapk8increases expressionISOMAPK8 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of MAPK8 proteinPMID:16041517
Mapk8increases phosphorylationISOMAPK8 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased phosphorylation of MAPK8 proteinPMID:15698582
Mapk8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased phosphorylation of MAPK8 proteinPMID:18321868 PMID:35777681
Mapk8multiple interactionsISOMAPK8 (Homo sapiens)6480464CTDNitrogen Oxides inhibits the reaction [Benzo(a)pyrene results in increased expression of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Benzo(a)pyrene results in increased expression of MAPK8 protein]PMID:16041517
Mapk8multiple interactionsISOMapk8 (Mus musculus)6480464CTDCurcumin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK8 protein]; necrostatin-1 inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of MAPK8 protein]PMID:18321868 PMID:35777681
Go Back to source page   Continue to Ontology report