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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621424
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lig1
Name: DNA ligase 1
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lig1increases expressionEXP 6480464CTDAcetaminophen results in increased expression of LIG1 mRNAPMID:33387578
Lig1decreases expressionISOLig1 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of LIG1 mRNAPMID:17942131
Lig1increases expressionISOLIG1 (Homo sapiens)6480464CTDAcetaminophen results in increased expression of LIG1 mRNAPMID:22230336
Lig1increases expressionISOLig1 (Mus musculus)6480464CTDAcetaminophen results in increased expression of LIG1 mRNAPMID:12540782
Lig1multiple interactionsISOLig1 (Mus musculus)6480464CTDO(2)-vinyl-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate inhibits the reaction [Acetaminophen results in increased expression of LIG1 mRNA]PMID:12540782
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