GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nr1i3 | increases activity | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | o-Aminoazotoluene results in increased activity of NR1I3 protein | PMID:21672546 | Nr1i3 | increases response to substance | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | NR1I3 protein results in increased susceptibility to o-Aminoazotoluene | PMID:21672546 | Nr1i3 | multiple interactions | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC2 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of ABCC4 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2B10 protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP2C29 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of CYP3A11 mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC mRNA]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of MYC protein]; NR1I3 gene mutant form inhibits the reaction [o-Aminoazotoluene results in increased expression of UGT1A1 mRNA] | PMID:21672546 | | ||||||||||||||||||||||
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