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GENE - TERM ANNOTATION REPORT

RGD ID: 621375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ikbkb
Name: inhibitor of nuclear factor kappa B kinase subunit beta
Acc ID: GO:0008385
Term: IkappaB kinase complex
Definition: A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription.
Definition Source(s): GOC:bf, GOC:ma, PMID:12055104, PMID:20300203
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ikbkb IDA 2298661RGD  
Ikbkbpart_ofISOIKBKB (Homo sapiens)1624291RGD PMID:20434986

PMID:20434986
Ikbkbpart_ofISOIkbkb (Mus musculus)1624291RGD PMID:10229185 PMID:20434986

PMID:10229185 PMID:20434986
Ikbkbpart_ofIBAMGI:1338071 or MGI:99484 or PANTHER:PTN000540281 or Chuk (Rattus norvegicus) or Ikbkb (Rattus norvegicus) or UniProtKB:O14920 or UniProtKB:O151111600115GO_CentralGO_REF:0000033

GO_REF:0000033
Ikbkbpart_ofIEAARBA:ARBA000450441600115UniProtGO_REF:0000117

GO_REF:0000117
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