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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621317
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp3
Name: matrix metallopeptidase 3
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp3increases expressionISOMMP3 (Homo sapiens)6480464CTDNicotine results in increased expression of MMP3 mRNA; Nicotine results in increased expression of MMP3 proteinPMID:17151781 PMID:18986645
Mmp3multiple interactionsISOMMP3 (Homo sapiens)6480464CTDlipopolysaccharide, E. coli O26-B6 promotes the reaction [Nicotine results in increased expression of MMP3 mRNA]; Nicotine promotes the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of MMP3 mRNA]PMID:18986645
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