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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expression ISOMMP2 (Homo sapiens)127284886RGDcisplatin decreases expression of MMP2 protein in stomach  
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDCisplatin results in decreased activity of MMP2 proteinPMID:31303961
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of MMP2 proteinPMID:30396169 PMID:34687144
Mmp2decreases expressionISOMmp2 (Mus musculus)6480464CTDCisplatin results in decreased expression of MMP2 mRNAPMID:29148169
Mmp2increases activityISOMMP2 (Homo sapiens)6480464CTDCisplatin results in increased activity of MMP2 proteinPMID:21618587
Mmp2increases expressionISOMMP2 (Homo sapiens)6480464CTDCisplatin results in increased expression of MMP2 mRNAPMID:21618587
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of MMP2 mRNA; [Cisplatin co-treated with Paclitaxel] results in increased expression of MMP2 mRNA; [Glycyrrhizic Acid co-treated with Cisplatin] results in decreased expression of MMP2 mRNA; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of MMP2 protein; Cisplatin promotes the reaction [SC-66 compound results in decreased expression of MMP2 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride promotes the reaction [Cisplatin results in decreased activity of MMP2 protein]; SC-66 compound promotes the reaction [Cisplatin results in decreased expression of MMP2 protein]PMID:20705681 PMID:27392435 PMID:30291867 PMID:31303961 PMID:34687144 PMID:37659683
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDCisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP2 protein]; Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP2 mRNA]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP2 protein]]; Cisplatin promotes the reaction [NPPC protein inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP2 mRNA]]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of and results in increased activity of MMP2 protein]]; NPPC protein promotes the reaction [Cisplatin inhibits the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Croton Oil] results in increased expression of MMP2 mRNA]]PMID:37352108
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