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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hspd1
Name: heat shock protein family D (Hsp60) member 1
Acc ID: CHEBI:6980
Term: monocrotaline
Definition: A pyrrolizidine alkaloid that has formula C16H23NO6.
Chemical ID: MESH:D016686
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hspd1affects expressionEXP 6480464CTDMonocrotaline affects the expression of HSPD1 proteinPMID:31589899
Hspd1increases secretionEXP 6480464CTDMonocrotaline results in increased secretion of HSPD1 proteinPMID:31504964
Hspd1multiple interactionsEXP 6480464CTDliquiritigenin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]; liquiritin inhibits the reaction [Monocrotaline affects the expression of HSPD1 protein]PMID:31589899
Hspd1increases secretionISOHspd1 (Mus musculus)6480464CTDMonocrotaline results in increased secretion of HSPD1 proteinPMID:31504964
Hspd1multiple interactionsISOHspd1 (Mus musculus)6480464CTD[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in decreased expression of HSPD1 mRNAPMID:21224054
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