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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621120
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk4
Name: cyclin-dependent kinase 4
Acc ID: CHEBI:17688
Term: (S)-nicotine
Definition: A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has S-configuration. The naturally occurring and most active enantiomer of nicotine, isolated from Nicotiana tabacum.
Chemical ID: MESH:D009538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk4decreases expressionISOCDK4 (Homo sapiens)6480464CTDNicotine results in decreased expression of CDK4 proteinPMID:15231866
Cdk4decreases expressionISOCdk4 (Mus musculus)6480464CTDNicotine results in decreased expression of CDK4 mRNA; Nicotine results in decreased expression of CDK4 proteinPMID:17135361
Cdk4multiple interactionsISOCDK4 (Homo sapiens)6480464CTDBungarotoxins inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Dihydro-beta-Erythroidine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Hexamethonium inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]; Nicotine promotes the reaction [CDK4 protein binds to CCND1 protein]; Nicotine promotes the reaction [NFATC2 protein results in decreased expression of CDK4 protein]; Tubocurarine inhibits the reaction [Nicotine results in decreased expression of CDK4 protein]PMID:15231866 PMID:18805435
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