GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Socs3 | affects expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of SOCS3 mRNA | PMID:22298810 | Socs3 | increases expression | EXP | | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA | PMID:32109520 PMID:33387578 | Socs3 | affects expression | ISO | Socs3 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin affects the expression of SOCS3 mRNA | PMID:21570461 | Socs3 | increases expression | ISO | SOCS3 (Homo sapiens) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA | PMID:21496263 | Socs3 | increases expression | ISO | Socs3 (Mus musculus) | 6480464 | CTD | Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA | PMID:17407152 PMID:18684927 PMID:18691609 PMID:19063610 PMID:19770486 PMID:20819909 PMID:21496263 PMID:25975270 | Socs3 | multiple interactions | ISO | SOCS3 (Homo sapiens) | 6480464 | CTD | [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased expression of SOCS3 mRNA | PMID:19578757 | Socs3 | multiple interactions | ISO | Socs3 (Mus musculus) | 6480464 | CTD | [Dietary Fats affects the susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of SOCS3 mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SOCS3 mRNA; Arachidonic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]; arachidonyltrifluoromethane inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]; Colforsin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SOCS3 gene] | PMID:17407152 PMID:19063610 PMID:20819909 PMID:25975270 PMID:28774668 | | ||||||||||||||||||||||
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