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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621063
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Csf1
Name: colony stimulating factor 1
Acc ID: CHEBI:145373
Term: pexidartinib
Definition: A pyrrolopyridine that is 5-chloro-1H-pyrrolo[2,3-b]pyridine which is substituted by a [6-({[6-(trifluoromethyl)pyridin-3-yl]methyl}amino)pyridin-3-yl]methyl group at position 3. It is a potent multi-targeted receptor tyrosine kinase inhibitor of CSF-1R, KIT, and FLT3 (IC50 of 20 nM, 10 nM and 160 nM, respectively). Approved by the FDA for the treatment of adult patients with symptomatic tenosynovial giant cell tumor (TGCT).
Chemical ID: MESH:C000600259
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Csf1decreases secretionISOCSF1 (Homo sapiens)6480464CTDpexidartinib results in decreased secretion of CSF1 proteinPMID:36368339
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