GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mlh1 | decreases expression | ISO | MLH1 (Homo sapiens) | 6480464 | CTD | chromium hexavalent ion results in decreased expression of MLH1 mRNA | PMID:19376149 PMID:30690063 | Mlh1 | decreases response to substance | ISO | MLH1 (Homo sapiens) | 6480464 | CTD | MLH1 gene mutant form results in decreased susceptibility to chromium hexavalent ion | PMID:15831465 | Mlh1 | increases response to substance | ISO | MLH1 (Homo sapiens) | 6480464 | CTD | MLH1 protein results in increased susceptibility to chromium hexavalent ion | PMID:17301063 | Mlh1 | increases response to substance | ISO | Mlh1 (Mus musculus) | 6480464 | CTD | MLH1 protein results in increased susceptibility to chromium hexavalent ion | PMID:15831465 | Mlh1 | multiple interactions | ISO | MLH1 (Homo sapiens) | 6480464 | CTD | Ascorbic Acid promotes the reaction [MLH1 gene mutant form results in decreased susceptibility to chromium hexavalent ion]; MLH1 protein affects the reaction [chromium hexavalent ion affects the activity of CASP3 protein]; MLH1 protein affects the reaction [chromium hexavalent ion results in increased activity of CASP2 protein]; MLH1 protein affects the reaction [chromium hexavalent ion results in increased activity of CASP7 protein]; MLH1 protein affects the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein]; MLH1 protein promotes the reaction [Ascorbic Acid results in increased susceptibility to chromium hexavalent ion]; MLH1 protein results in increased susceptibility to [chromium hexavalent ion co-treated with Ascorbic Acid] | PMID:15831465 PMID:17169990 PMID:17301063 | | ||||||||||||||||||||||
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