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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionEXP 6480464CTDCisplatin results in decreased expression of PPARGC1A; Cisplatin results in decreased expression of PPARGC1A mRNAPMID:33661552 PMID:36006825 PMID:39102946
Ppargc1aincreases acetylationEXP 6480464CTDCisplatin results in increased acetylation of PPARGC1A proteinPMID:33661552
Ppargc1amultiple interactionsEXP 6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA]]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [betanin inhibits the reaction [Cisplatin results in increased acetylation of PPARGC1A protein]]; betanin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA]; betanin inhibits the reaction [Cisplatin results in increased acetylation of PPARGC1A protein]; Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A]PMID:33661552 PMID:39102946
Ppargc1adecreases expressionISOPpargc1a (Mus musculus)6480464CTDCisplatin results in decreased expression of PPARGC1A mRNA; Cisplatin results in decreased expression of PPARGC1A proteinPMID:32567747 PMID:35367536 PMID:37179038
Ppargc1amultiple interactionsISOPpargc1a (Mus musculus)6480464CTDAspirin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA]; Linagliptin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A protein]; Melatonin inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A mRNA]PMID:32567747 PMID:35367536 PMID:37179038
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTD[NNT protein inhibits the reaction [NNT protein modified form results in decreased susceptibility to Cisplatin]] which results in decreased expression of PPARGC1A mRNA; Nicotinamide Mononucleotide inhibits the reaction [[NNT protein inhibits the reaction [NNT protein modified form results in decreased susceptibility to Cisplatin]] which results in decreased expression of PPARGC1A mRNA]; PPARGC1A protein affects the reaction [SRT1720 affects the reaction [Cisplatin results in decreased expression of and results in decreased phosphorylation of NFE2L2 protein]]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in decreased expression of HMOX1 mRNA]]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA]]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in increased expression of CXCL8 protein]]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in increased expression of MMP1 protein]]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in increased expression of MMP13 protein]]; PPARGC1A protein affects the reaction [SRT1720 inhibits the reaction [Cisplatin results in increased expression of PTGS2 protein]]; SRT1720 inhibits the reaction [Cisplatin results in decreased expression of PPARGC1A protein]PMID:36336710 PMID:37497868
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