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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620925
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ppargc1a
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:17634
Term: D-glucose
Definition: A glucose with D-configuration.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1aaffects expressionEXP 6480464CTDGlucose affects the expression of PPARGC1A mRNAPMID:24349266
Ppargc1adecreases expressionEXP 6480464CTDGlucose results in decreased expression of PPARGC1A mRNA; Glucose results in decreased expression of PPARGC1A proteinPMID:31639451 PMID:35243728 PMID:37944786
Ppargc1amultiple interactionsEXP 6480464CTD[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of PPARGC1A protein; formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; formononetin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; Inositol inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; qishen yiqi inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of PPARGC1A protein]; SRT1720 inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]PMID:31639451 PMID:35243728 PMID:36806343 PMID:37944786
Ppargc1adecreases expressionISOPpargc1a (Mus musculus)6480464CTDGlucose results in decreased expression of PPARGC1A mRNA; Glucose results in decreased expression of PPARGC1A proteinPMID:23090186 PMID:28482072 PMID:34485530
Ppargc1adecreases expressionISOPPARGC1A (Homo sapiens)6480464CTDGlucose deficiency results in decreased expression of PPARGC1A mRNA; Glucose results in decreased expression of PPARGC1A mRNA; Glucose results in decreased expression of PPARGC1A proteinPMID:17855661 PMID:33957017 PMID:35445903 PMID:36156098
Ppargc1aincreases acetylationISOPPARGC1A (Homo sapiens)6480464CTDGlucose results in increased acetylation of PPARGC1A proteinPMID:19071085
Ppargc1aincreases expressionISOPPARGC1A (Homo sapiens)6480464CTDGlucose deficiency results in increased expression of PPARGC1A mRNA; Glucose results in increased expression of PPARGC1A mRNAPMID:26811028 PMID:33962019
Ppargc1amultiple interactionsISOPpargc1a (Mus musculus)6480464CTD4-phenylbutyric acid inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; [SIRT1 protein co-treated with Resveratrol] affects the reaction [Glucose affects the expression of PPARGC1A protein]; AICA ribonucleotide inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; CEBPB protein inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; DDIT3 affects the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; Glucose inhibits the reaction [DDIT3 protein binds to PPARGC1A promoter]; Metformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A mRNA]; morroniside inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]PMID:23090186 PMID:28482072 PMID:34485530
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [ACACB protein affects the reaction [Glucose results in decreased expression of PPARGC1A protein]]; [Glucose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A mRNA; [Glucose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein; [Pyruvic Acid co-treated with Glucose] results in decreased acetylation of PPARGC1A protein; ACACB protein affects the reaction [Glucose results in decreased expression of PPARGC1A protein]; acadesine inhibits the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A mRNA]; acadesine inhibits the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein]; dorsomorphin promotes the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A mRNA]; dorsomorphin promotes the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein]; Glucose promotes the reaction [YY1 protein binds to PPARGC1A promoter]; Nitroprusside inhibits the reaction [Glucose deficiency results in decreased expression of PPARGC1A mRNA]; PPARGC1A protein affects the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of PPARA mRNA]; PPARGC1A protein affects the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of PPARG mRNA]; PPARGC1A protein affects the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of TERT mRNA]; PPARGC1A protein affects the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of TERT protein]; PPARGC1A protein affects the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of TFAM mRNA]; TERT protein inhibits the reaction [[Glucose co-treated with Palmitic Acid] results in decreased expression of PPARGC1A protein]; YY1 promotes the reaction [Glucose results in decreased expression of PPARGC1A protein]PMID:17855661 PMID:19071085 PMID:33957017 PMID:35445903 PMID:39265716
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