Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620873
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il23a
Name: interleukin 23 subunit alpha
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il23aincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IL23A mRNAPMID:21742974
Il23amultiple interactionsEXP 6480464CTDMIRLET7I mRNA affects the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]PMID:21742974
Il23aaffects expressionISOIL23A (Homo sapiens)6480464CTDLipopolysaccharides affects the expression of IL23A proteinPMID:24749687
Il23aincreases expressionISOIl23a (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of IL23A mRNAPMID:17464197 PMID:21989142 PMID:23999131 PMID:33049506
Il23aincreases expressionISOIL23A (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IL23A mRNAPMID:15516327 PMID:15860229 PMID:35811015
Il23aincreases secretionISOIl23a (Mus musculus)6480464CTDLipopolysaccharides results in increased secretion of IL23A proteinPMID:33049506
Il23aincreases secretionISOIL23A (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of IL23A proteinPMID:22127699
Il23amultiple interactionsISOIl23a (Mus musculus)6480464CTD[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; [sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]; hydroquinone inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; Tetrachlorodibenzodioxin promotes the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]; tricarbonyldichlororuthenium (II) dimer inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] inhibits the reaction [Lipopolysaccharides results in increased secretion of IL23A protein]]PMID:17464197 PMID:21989142 PMID:23999131 PMID:33049506
Il23amultiple interactionsISOIL23A (Homo sapiens)6480464CTD2-(1'H-indole-3'-carbonyl)thiazole-4-carboxylic acid methyl ester affects the reaction [Lipopolysaccharides affects the expression of IL23A protein]; 6-formylindolo(3,2-b)carbazole affects the reaction [Lipopolysaccharides affects the expression of IL23A protein]; [Lipopolysaccharides co-treated with resiquimod] results in increased expression of [IL12B protein binds to IL23A protein]; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of IL23A mRNA; apilimod inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased secretion of [IL23A protein binds to IL12B protein]]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of IL23A mRNA]PMID:17053051 PMID:18490488 PMID:24749687 PMID:35811015
Go Back to source page   Continue to Ontology report