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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620865
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lif
Name: LIF, interleukin 6 family cytokine
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lifdecreases expressionISOLIF (Homo sapiens)6480464CTDCisplatin results in decreased expression of LIF mRNAPMID:27392435
Lifincreases expressionISOLIF (Homo sapiens)6480464CTDCisplatin results in increased expression of LIF mRNAPMID:21532991 PMID:26198647
Lifincreases expressionISOLif (Mus musculus)6480464CTDCisplatin results in increased expression of LIF mRNAPMID:19833167
Lifmultiple interactionsISOLIF (Homo sapiens)6480464CTD[Cisplatin co-treated with jinfukang] results in decreased expression of LIF mRNAPMID:27392435
Lifmultiple interactionsISOLif (Mus musculus)6480464CTDIL6 gene mutant form promotes the reaction [Cisplatin results in increased expression of LIF mRNA]PMID:19833167
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