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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620784
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfsf11
Name: TNF superfamily member 11
Acc ID: CHEBI:28940
Term: calciol
Definition: A hydroxy seco-steroid that is (5Z,7E)-9,10-secocholesta-5,7,10(19)-triene in which the pro-S hydrogen at position 3 has been replaced by a hydroxy group. It is the inactive form of vitamin D3, being hydroxylated in the liver to calcidiol (25-hydroxyvitamin D3), which is then further hydroxylated in the kidney to give calcitriol (1,25-dihydroxyvitamin D3), the active hormone.
Chemical ID: MESH:D002762
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfsf11increases expressionISOTNFSF11 (Homo sapiens)6480464CTDCholecalciferol results in increased expression of TNFSF11 mRNAPMID:17996099
Tnfsf11increases expressionISOTnfsf11 (Mus musculus)6480464CTDCholecalciferol results in increased expression of TNFSF11 mRNAPMID:17008384
Tnfsf11multiple interactionsISOTNFSF11 (Homo sapiens)6480464CTD[Chondroitin Sulfates co-treated with Glucosamine] inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]; Chondroitin Sulfates inhibits the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]PMID:17996099
Tnfsf11multiple interactionsISOTnfsf11 (Mus musculus)6480464CTDCholecalciferol promotes the reaction [[RXRB protein binds to VDR protein] which binds to TNFSF11 promoter]; decitabine promotes the reaction [Cholecalciferol results in increased expression of TNFSF11 mRNA]PMID:17008384
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