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GENE - TERM ANNOTATION REPORT

RGD ID: 620600
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nox4
Name: NADPH oxidase 4
Acc ID: GO:0043020
Term: NADPH oxidase complex
Definition: A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires the cytosolic regulatory subunits at least NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2.
Definition Source(s): GOC:jl, PMID:11483596, PMID:12440767
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nox4 IDA 1580287RGD  
Nox4part_ofIBAMGI:2681162 or MGI:88574 or PANTHER:PTN000239643 or Cybb (Rattus norvegicus) or Nox1 (Rattus norvegicus) or Nox4 (Rattus norvegicus) or UniProtKB:P04839 or UniProtKB:Q9Y5S81600115GO_CentralGO_REF:0000033

GO_REF:0000033
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