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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620545
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Chek1
Name: checkpoint kinase 1
Acc ID: CHEBI:44423
Term: hydroxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Chemical ID: MESH:D006918
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Chek1decreases expressionISOChek1 (Mus musculus)6480464CTDHydroxyurea results in decreased expression of CHEK1 mRNAPMID:12929121
Chek1increases expressionISOCHEK1 (Homo sapiens)6480464CTDHydroxyurea results in increased expression of CHK1 protein modified formPMID:21840268
Chek1increases phosphorylationISOCHEK1 (Homo sapiens)6480464CTDHydroxyurea results in increased phosphorylation of CHEK1 proteinPMID:32466334
Chek1multiple interactionsISOCHEK1 (Homo sapiens)6480464CTDCaffeine inhibits the reaction [Hydroxyurea promotes the reaction [ATR protein results in increased phosphorylation of and results in increased activity of CHEK1 protein]]PMID:18158334
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