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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:68232
Term: (Z)-ligustilide
Definition: A butenolide that has formula C12H14O2.
Chemical ID: MESH:C027820
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein affects the susceptibility to ligustilidePMID:30243965
Nfe2l2decreases methylationISONfe2l2 (Mus musculus)6480464CTDligustilide results in decreased methylation of NFE2L2 promoterPMID:23441843
Nfe2l2increases methylationISONFE2L2 (Homo sapiens)6480464CTDligustilide results in increased methylation of NFE2L2 promoterPMID:30243965
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTDligustilide results in increased expression of and affects the localization of NFE2L2 proteinPMID:30243965
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