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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects expressionEXP 6480464CTDParaquat affects the expression of NFE2L2 proteinPMID:31715309
Nfe2l2affects localizationEXP 6480464CTDParaquat affects the localization of NFE2L2 proteinPMID:22678742 PMID:32064027 PMID:35707280
Nfe2l2decreases expressionEXP 6480464CTDParaquat results in decreased expression of NFE2L2 mRNA; Paraquat results in decreased expression of NFE2L2 proteinPMID:28624451 PMID:35236239
Nfe2l2increases expressionEXP 6480464CTDParaquat results in increased expression of NFE2L2 mRNA; Paraquat results in increased expression of NFE2L2 proteinPMID:20095329 PMID:24812154 PMID:25169090 PMID:26598004 PMID:32064027
Nfe2l2increases phosphorylationEXP 6480464CTDParaquat results in increased phosphorylation of NFE2L2 proteinPMID:30112919
Nfe2l2increases response to substanceEXP 6480464CTDNFE2L2 protein results in increased susceptibility to ParaquatPMID:22678742
Nfe2l2multiple interactionsEXP 6480464CTD[Mifepristone co-treated with Paraquat] results in increased expression of NFE2L2 mRNA; [sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]]; [sodium bisulfide results in increased abundance of Hydrogen Sulfide] promotes the reaction [Paraquat affects the localization of NFE2L2 protein]; [sodium bisulfide results in increased abundance of Hydrogen Sulfide] promotes the reaction [Paraquat results in increased expression of NFE2L2 protein]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; Estradiol affects the reaction [Paraquat affects the expression of NFE2L2 protein]; ginkgolide C inhibits the reaction [Paraquat affects the localization of NFE2L2 protein]; MIR136 promotes the reaction [Paraquat results in decreased expression of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in decreased expression of BCL2 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased activity of CASP3 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased activity of CASP7 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of BAK1 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of BAX mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of CASP12 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of DDIT3 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of DDIT3 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of HSPA5 mRNA]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of HSPA5 protein]; NFE2L2 mutant form inhibits the reaction [Paraquat results in increased expression of TP53 mRNA]; NFE2L2 protein affects the reaction [[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased cleavage of CASP1 protein]]; NFE2L2 protein affects the reaction [[sodium bisulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in increased expression of NLRP3 protein]]; NFE2L2 protein affects the reaction [[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in decreased expression of SIRT3 protein]]; NFE2L2 protein affects the reaction [Paraquat results in decreased expression of SIRT3 protein]; NFE2L2 protein affects the reaction [Paraquat results in increased cleavage of CASP1 protein]; NFE2L2 protein affects the reaction [Paraquat results in increased expression of NLRP3 protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in decreased activity of CAT protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of IL1B protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of IL6 protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of RELA protein]; NFE2L2 protein inhibits the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of TNF protein]; NFE2L2 protein promotes the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [[Mifepristone co-treated with Paraquat] results in increased expression of NQO1 mRNA]; NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in decreased expression of CDH1 protein]]; NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of SNAI1 protein]]; NFE2L2 protein promotes the reaction [Sirolimus inhibits the reaction [Paraquat results in increased expression of VIM protein]]; Paraquat promotes the reaction [KEAP1 protein binds to NFE2L2 protein]; Resveratrol inhibits the reaction [MIR136 promotes the reaction [Paraquat results in decreased expression of NFE2L2 protein]]; Resveratrol inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of NFE2L2 mRNA]; Sirolimus inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; Unithiol promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]PMID:20095329 PMID:22678742 PMID:24812154 PMID:25169090 PMID:28624451 PMID:31715309 PMID:32064027 PMID:35236239 PMID:35707280
Nfe2l2affects expressionISONFE2L2 (Homo sapiens)6480464CTDParaquat affects the expression of NFE2L2 proteinPMID:28428137
Nfe2l2affects expressionISONfe2l2 (Mus musculus)6480464CTDParaquat affects the expression of NFE2L2 proteinPMID:28428137 PMID:29071302
Nfe2l2affects localizationISONfe2l2 (Mus musculus)6480464CTDParaquat affects the localization of NFE2L2 proteinPMID:30562684 PMID:30571954
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the susceptibility to ParaquatPMID:29950142
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDParaquat results in decreased expression of NFE2L2 mRNA; Paraquat results in decreased expression of NFE2L2 proteinPMID:20851755 PMID:24866057 PMID:31385236
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDParaquat results in decreased expression of NFE2L2 mRNA; Paraquat results in decreased expression of NFE2L2 proteinPMID:17215068 PMID:26758514 PMID:30571954 PMID:30744607 PMID:33838153
Nfe2l2decreases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein results in decreased susceptibility to ParaquatPMID:22493042
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDParaquat results in increased expression of NFE2L2 mRNA; Paraquat results in increased expression of NFE2L2 proteinPMID:22709784 PMID:23546295 PMID:23649336 PMID:24141985 PMID:24561720 PMID:26649146 PMID:35641671 PMID:37507096
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDParaquat results in increased expression of NFE2L2 mRNA; Paraquat results in increased expression of NFE2L2 proteinPMID:22983789 PMID:25579023 PMID:26708779 PMID:28115273 PMID:29950142 PMID:32540480
Nfe2l2increases phosphorylationISONfe2l2 (Mus musculus)6480464CTDParaquat results in increased phosphorylation of NFE2L2 proteinPMID:27788593
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in decreased expression of IL10 protein]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of CASP3 mRNA]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of CASP9 mRNA]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of CYCS mRNA]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of IL10 mRNA]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of IL6 protein]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; [Mifepristone co-treated with NFE2L2 protein] inhibits the reaction [Paraquat results in increased expression of TNF protein]; [naringenin co-treated with Paraquat] results in increased expression of NFE2L2 protein; [Paraquat co-treated with Ellagic Acid] results in increased expression of and affects the localization of NFE2L2 protein; [Paraquat co-treated with Ellagic Acid] results in increased expression of NFE2L2 mRNA; [Paraquat co-treated with Quercetin] results in increased expression of NFE2L2 mRNA; [Paraquat co-treated with Quercetin] results in increased localization of NFE2L2 protein; [Paraquat co-treated with Thioctic Acid] results in increased expression of and affects the localization of NFE2L2 protein; [Resveratrol results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Paraquat; [Silymarin co-treated with Paraquat] results in increased expression of NFE2L2 protein; [SIRT6 protein results in decreased susceptibility to Paraquat] inhibits the reaction [NFE2L2 protein binds to HMOX1 enhancer]; Acetylcysteine inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the expression of NFE2L2 protein]; CAT protein inhibits the reaction [Paraquat results in decreased expression of NFE2L2 mRNA]; Meloxicam inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; NFE2L2 mRNA promotes the reaction [Paraquat promotes the reaction [SIRT6 protein binds to HMOX1 gene]]; NFE2L2 protein affects the reaction [ERBB2 protein results in decreased susceptibility to Paraquat]; NFE2L2 protein inhibits the reaction [Paraquat results in decreased expression of GPX4 protein]; NFE2L2 protein inhibits the reaction [Paraquat results in decreased expression of SLC7A11 protein]; NFE2L2 protein inhibits the reaction [Paraquat results in increased expression of IL6 protein]; NFE2L2 protein inhibits the reaction [Paraquat results in increased expression of SQSTM1 protein]; NFE2L2 protein inhibits the reaction [Paraquat results in increased expression of TGFB1 protein]; NFE2L2 protein inhibits the reaction [Paraquat results in increased expression of TNF protein]; NFE2L2 protein promotes the reaction [Paraquat results in increased expression of COL28A1 mRNA]; NFE2L2 protein promotes the reaction [Paraquat results in increased expression of SLC40A1 protein]; NFE2L2 protein promotes the reaction [Paraquat results in increased expression of SQSTM1 protein]; Paraquat promotes the reaction [MIR153 mRNA binds to NFE2L2 3' UTR]; Paraquat promotes the reaction [Plant Extracts affects the localization of NFE2L2 protein]; Paraquat promotes the reaction [Resveratrol results in increased expression of and results in increased activity of NFE2L2 protein]; Paraquat promotes the reaction [Silymarin affects the localization of NFE2L2 protein]; Paraquat results in increased expression of and results in increased activity of NFE2L2 protein; Plant Extracts promotes the reaction [Paraquat results in increased expression of NFE2L2 protein]; Silymarin promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thioctic Acid promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]PMID:20851755 PMID:22493042 PMID:22709784 PMID:22736252 PMID:22996356 PMID:23546295 PMID:23649336 PMID:24141985 PMID:24561720 PMID:24866057 PMID:25467193 PMID:28428137 PMID:31216030 PMID:33495402 PMID:37507096
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [Paraquat results in increased expression of NFE2L2 protein]; [HFE protein alternative form affects the susceptibility to Paraquat] which affects the expression of NFE2L2; AKT2 protein affects the reaction [Paraquat results in increased expression of NFE2L2 protein]; ARL6IP5 protein affects the reaction [Paraquat affects the expression of NFE2L2 protein]; HFE protein alternative form affects the reaction [Paraquat results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [HFE protein alternative form affects the susceptibility to Paraquat]; NFE2L2 protein affects the reaction [Paraquat affects the expression of MIR380 mRNA]; NFE2L2 protein affects the reaction [Paraquat affects the expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Paraquat results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Paraquat results in increased expression of LAMP2 protein alternative form]; NFE2L2 protein affects the reaction [Paraquat results in increased expression of MIR195 mRNA]; NFE2L2 protein affects the reaction [Paraquat results in increased expression of MIR669B mRNA]; Paraquat affects the expression of and results in decreased stability of NFE2L2 protein; Paraquat inhibits the reaction [NFE2L2 protein binds to MIR380 promoter]; PARK7 gene mutant form affects the reaction [Paraquat affects the expression of NFE2L2 protein]; plant extract, Puerariae Radix inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; resolvin D1 analog inhibits the reaction [Paraquat affects the localization of NFE2L2 protein]; resolvin D1 inhibits the reaction [Paraquat affects the localization of NFE2L2 protein]; resolvin D1 inhibits the reaction [Paraquat results in decreased expression of NFE2L2 mRNA]; rhyncophylline inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; SIRT1 protein inhibits the reaction [Paraquat results in decreased stability of NFE2L2 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]; Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 protein]PMID:17823202 PMID:22983789 PMID:25579023 PMID:26758514 PMID:26935021 PMID:28115273 PMID:28428137 PMID:29071302 PMID:29950142 PMID:30562684 PMID:30571954 PMID:30744607 PMID:31368498 PMID:32540480 PMID:33838153
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