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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects localizationEXP 6480464CTDlead acetate affects the localization of NFE2L2 proteinPMID:32116774
Nfe2l2decreases expressionEXP 6480464CTDlead acetate results in decreased expression of NFE2L2 mRNA; lead acetate results in decreased expression of NFE2L2 proteinPMID:26797587 PMID:32116774 PMID:32208856 PMID:33862172 PMID:37471654
Nfe2l2increases expressionEXP 6480464CTDlead acetate results in increased expression of NFE2L2 mRNAPMID:23274417 PMID:34051273
Nfe2l2multiple interactionsEXP 6480464CTD2-tert-butylhydroquinone promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; 5,7,3',4'-tetramethylluteolin inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein; Cholecalciferol promotes the reaction [lead acetate results in increased expression of NFE2L2 mRNA]; coenzyme Q10 inhibits the reaction [lead acetate affects the localization of NFE2L2 protein]; coenzyme Q10 inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; Deferoxamine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; ferrostatin-1 inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 protein]; ferrostatin-1 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; Genistein inhibits the reaction [lead acetate results in decreased expression of NFE2L2 protein]; lead acetate promotes the reaction [Zinc Oxide results in increased expression of and affects the localization of NFE2L2 protein]; lead acetate results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NQO1 protein]; NFE2L2 protein results in decreased susceptibility to [lead acetate results in increased abundance of Lead]; sinapinic acid inhibits the reaction [lead acetate results in decreased expression of NFE2L2 mRNA]; Zinc Oxide promotes the reaction [lead acetate results in increased expression of and affects the localization of NFE2L2 protein]PMID:23274417 PMID:26797587 PMID:30476502 PMID:32116774 PMID:32208856 PMID:34051273 PMID:34553816 PMID:37471654 PMID:39276841
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDlead acetate results in increased activity of NFE2L2 proteinPMID:30114225
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDlead acetate results in increased expression of NFE2L2 mRNAPMID:26498409
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[lead acetate results in increased abundance of Lead] inhibits the reaction [Ascorbic Acid results in increased expression of NFE2L2 protein]; [lead acetate results in increased abundance of Lead] inhibits the reaction [Rosmarinic Acid results in increased expression of NFE2L2 protein]; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA; Ascorbic Acid promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; lead acetate results in increased activity of and affects the localization of NFE2L2 protein; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased activity of and affects the localization of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLC mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GCLM mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GSTA1 mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [lead acetate results in increased expression of SPP1 mRNA]; NFE2L2 protein inhibits the reaction [lead acetate results in decreased expression of BCL2 protein]; NFE2L2 protein inhibits the reaction [lead acetate results in increased activity of CASP3 protein]; NFE2L2 protein inhibits the reaction [lead acetate results in increased expression of BAX protein]; Rosmarinic Acid affects the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]PMID:26498409 PMID:27562236 PMID:31610155
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in decreased expression of NFE2L2 protein; [[Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] co-treated with [lead acetate results in increased abundance of Lead]] results in increased expression of NFE2L2 mRNA; [lead acetate results in increased abundance of Lead] which results in decreased expression of NFE2L2 protein; [lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA; [Microplastics results in increased abundance of [Polyvinyl Chloride co-treated with Polyethylene]] promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of NFE2L2 mRNA]; Fatty Acids, Omega-3 inhibits the reaction [lead acetate results in decreased expression of and affects the localization of NFE2L2 protein]; lead acetate results in decreased expression of and affects the localization of NFE2L2 proteinPMID:35527006 PMID:38180308
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