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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of NFE2L2 mRNA; Arsenic Trioxide results in decreased expression of NFE2L2 proteinPMID:24327821 PMID:29297235 PMID:31258454 PMID:32920515
Nfe2l2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of NFE2L2 mRNA; Arsenic Trioxide results in increased expression of NFE2L2 proteinPMID:27592447 PMID:27713174 PMID:28978146 PMID:29223816 PMID:29986281
Nfe2l2multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of and affects the localization of NFE2L2 protein]; alpha-Tocopherol inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 mRNA]; Arsenic Trioxide results in increased expression of and affects the localization of NFE2L2 protein; Arsenic Trioxide results in increased phosphorylation of and affects the localization of NFE2L2 protein; Ascorbic Acid inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 mRNA]; Buthionine Sulfoximine promotes the reaction [Arsenic Trioxide results in increased expression of and affects the localization of NFE2L2 protein]; crocin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; eriodictyol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; oxymatrine promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Resveratrol inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 mRNA]PMID:24327821 PMID:24634002 PMID:27713174 PMID:28978146 PMID:29297235 PMID:29986281 PMID:32920515
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDArsenic Trioxide affects the localization of NFE2L2 proteinPMID:19350554 PMID:25003661 PMID:26283888
Nfe2l2affects response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein affects the susceptibility to Arsenic TrioxidePMID:20707922
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDArsenic Trioxide results in decreased expression of NFE2L2 proteinPMID:22155346 PMID:27561292
Nfe2l2decreases expressionISONfe2l2 (Mus musculus)6480464CTDArsenic Trioxide results in decreased expression of NFE2L2 proteinPMID:24157283 PMID:33603344 PMID:33846815
Nfe2l2decreases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 mRNA results in decreased susceptibility to Arsenic Trioxide; NFE2L2 protein results in decreased susceptibility to Arsenic TrioxidePMID:22684020 PMID:26708503
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of NFE2L2 mRNA; Arsenic Trioxide results in increased expression of NFE2L2 proteinPMID:22155346 PMID:22684020 PMID:24801890 PMID:25341331 PMID:26772155 PMID:29876539 PMID:30317545 PMID:35276128
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDArsenic Trioxide results in increased expression of NFE2L2 mRNA; Arsenic Trioxide results in increased expression of NFE2L2 proteinPMID:22488045 PMID:26187899
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of and affects the localization of NFE2L2 protein; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of NFE2L2 mRNA; [Arsenic Trioxide results in increased abundance of Arsenic] which results in increased expression of NFE2L2 protein; [Resveratrol co-treated with Arsenic Trioxide] results in increased expression of NFE2L2 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of NFE2L2 protein]; allicin inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; Arsenic Trioxide promotes the reaction [Resveratrol results in increased expression of NFE2L2 protein]; Arsenic Trioxide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 mRNA promotes the reaction [Ethionamide results in increased susceptibility to Arsenic Trioxide]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in decreased expression of ACTA2 protein]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein inhibits the reaction [Arsenic Trioxide results in increased abundance of Reactive Oxygen Species]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of KEAP1 protein]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of NQO1 protein]; NFE2L2 protein promotes the reaction [Arsenic Trioxide results in increased expression of PPARG mRNA]; NFE2L2 protein promotes the reaction [Rosiglitazone results in increased susceptibility to Arsenic Trioxide]; NFE2L2 protein promotes the reaction [Troglitazone results in increased susceptibility to Arsenic Trioxide]; Resveratrol promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; Tretinoin inhibits the reaction [Arsenic Trioxide affects the localization of NFE2L2 protein]PMID:19350554 PMID:21327864 PMID:22684020 PMID:25003661 PMID:26708503 PMID:26772155 PMID:27561292 PMID:29876539 PMID:30317545 PMID:33434570
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; 18alpha,20beta-hydroxy-11-oxo-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranurosyl-alpha-D-glucopyranosiduronate magnesium tetrahydrate inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; [Arsenic Trioxide co-treated with Grape Seed Proanthocyanidins] results in increased expression of NFE2L2 mRNA; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased expression of NFE2L2 protein]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 mRNA]; Arsenic Trioxide promotes the reaction [Lutein results in increased expression of NFE2L2 protein]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Lutein promotes the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in decreased expression of TNF protein]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Arsenic Trioxide results in increased expression of NQO1 mRNA]; SB 203580 inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 mRNA]; Thioctic Acid inhibits the reaction [Arsenic Trioxide results in increased expression of NFE2L2 protein]PMID:22488045 PMID:24157283 PMID:25815309 PMID:25966753 PMID:26187899 PMID:29049341 PMID:33603344 PMID:33846815
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