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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:27568
Term: selenium atom
Definition: A chalcogen that has formula Se.
Chemical ID: MESH:D012643
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2multiple interactionsEXP 6480464CTD[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Zinc co-treated with Selenium] inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]PMID:32233808 PMID:37415728
Nfe2l2affects activityISONfe2l2 (Mus musculus)6480464CTDSelenium affects the activity of NFE2L2 proteinPMID:18279678
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDSelenium results in decreased expression of NFE2L2 mRNAPMID:19244175
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD[Selenium co-treated with Vitamin E] results in decreased expression of NFE2L2 mRNAPMID:19244175
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTDNFE2L2 protein affects the reaction [Selenium affects the activity of HMOX1 protein]PMID:18279678
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