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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620349
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs2
Name: prostaglandin-endoperoxide synthase 2
Acc ID: CHEBI:29678
Term: sodium arsenite
Definition: An inoganic sodium salt with formula with formula NaAsO2.
Chemical ID: MESH:C017947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs2increases activityEXP 6480464CTDsodium arsenite results in increased activity of PTGS2 proteinPMID:22236721 PMID:24448467
Ptgs2increases expressionEXP 6480464CTDsodium arsenite results in increased expression of PTGS2; sodium arsenite results in increased expression of PTGS2 mRNA; sodium arsenite results in increased expression of PTGS2 proteinPMID:23137061 PMID:26439596 PMID:32593899
Ptgs2multiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTGS2 mRNA; sodium arsenite inhibits the reaction [Acetaminophen results in decreased activity of PTGS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2]; zingerone inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of PTGS2 mRNA]PMID:24448467 PMID:26439596 PMID:36822304
Ptgs2affects expressionISOPtgs2 (Mus musculus)6480464CTDsodium arsenite affects the expression of PTGS2 mRNAPMID:16507464
Ptgs2affects response to substanceISOPTGS2 (Homo sapiens)6480464CTDPTGS2 protein affects the susceptibility to sodium arsenitePMID:16809336
Ptgs2decreases expressionISOPTGS2 (Homo sapiens)6480464CTDsodium arsenite results in decreased expression of PTGS2 mRNA; sodium arsenite results in decreased expression of PTGS2 proteinPMID:21910007 PMID:23376440
Ptgs2decreases expressionISOPtgs2 (Mus musculus)6480464CTDsodium arsenite results in decreased expression of PTGS2 mRNAPMID:37682722
Ptgs2increases expressionISOPTGS2 (Homo sapiens)6480464CTDsodium arsenite results in increased expression of PTGS2 mRNA; sodium arsenite results in increased expression of PTGS2 proteinPMID:11835400 PMID:12377979 PMID:15056798 PMID:16809336 PMID:22714537 PMID:23376440 PMID:23968725 PMID:24570342 PMID:24961358 PMID:26220687 PMID:29301061 PMID:30090515 PMID:32593899 PMID:32890875 PMID:34032870 PMID:38568856
Ptgs2increases expressionISOPtgs2 (Mus musculus)6480464CTDsodium arsenite results in increased expression of PTGS2 mRNA; sodium arsenite results in increased expression of PTGS2 proteinPMID:16014739 PMID:20937726 PMID:21396911 PMID:22750630 PMID:25065748 PMID:36209798
Ptgs2multiple interactionsISOPTGS2 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; ACSL4 protein affects the reaction [sodium arsenite results in increased expression of PTGS2 protein]; AKT activator SC79 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]]; ATF2 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Buthionine Sulfoximine promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; CAT protein inhibits the reaction [Ethanol promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]]; CAT protein inhibits the reaction [sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 mRNA]]; Cyclosporine inhibits the reaction [sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 protein]]; ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Ethanol promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; Ethanol promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]; ferrostatin-1 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; LCN2 mutant form inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; Melatonin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; MFN2 protein affects the reaction [sodium arsenite results in increased expression of PTGS2 protein]; NFATC4 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]; pyrazolanthrone inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; Rosiglitazone inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; SB 203580 inhibits the reaction [Lapatinib inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; SB 203580 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 mRNA]; sodium arsenite promotes the reaction [Ethanol results in increased expression of PTGS2 protein]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; STAT3 protein promotes the reaction [sodium arsenite results in increased expression of PTGS2 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; U 0126 inhibits the reaction [ERBB2 protein affects the reaction [sodium arsenite results in increased expression of PTGS2 protein]]; U 0126 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 mRNA]; U 0126 inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]PMID:11835400 PMID:15056798 PMID:16809336 PMID:23376440 PMID:23968725 PMID:24570342 PMID:24961358 PMID:26220687 PMID:28444938 PMID:30090515 PMID:32593899 PMID:32890875
Ptgs2multiple interactionsISOPtgs2 (Mus musculus)6480464CTD4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein]; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 mRNA; [CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein; [sodium arsenite co-treated with Ethanol] results in increased expression of PTGS2 protein; [sodium arsenite results in increased abundance of arsenite] affects the reaction [CDKN1B protein affects the expression of PTGS2 mRNA]; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein; CDKN1B protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein]; CREB1 protein affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 mRNA]; CREB1 protein affects the reaction [[CDKN1B protein affects the susceptibility to [sodium arsenite results in increased abundance of arsenite]] which affects the expression of PTGS2 protein]; MAPK11 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein]; MAPK12 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of PTGS2 protein]; Telmisartan inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]PMID:22750630 PMID:23639288 PMID:26220687
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