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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620144
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ntrk1
Name: neurotrophic receptor tyrosine kinase 1
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ntrk1decreases expressionEXP 6480464CTDbisphenol A results in decreased expression of NTRK1 mRNAPMID:25181051
Ntrk1increases expressionEXP 6480464CTDbisphenol A results in increased expression of NTRK1 mRNAPMID:30816183 PMID:32528016 PMID:34947998
Ntrk1increases methylationEXP 6480464CTDbisphenol A results in increased methylation of NTRK1 genePMID:28505145
Ntrk1multiple interactionsEXP 6480464CTD[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in increased expression of NTRK1 mRNAPMID:25607892
Ntrk1decreases expressionISONtrk1 (Mus musculus)6480464CTDbisphenol A results in decreased expression of NTRK1 mRNA; bisphenol A results in decreased expression of NTRK1 proteinPMID:32365465 PMID:34655688
Ntrk1decreases expressionISONTRK1 (Homo sapiens)6480464CTDbisphenol A results in decreased expression of NTRK1 mRNAPMID:33670352
Ntrk1multiple interactionsISONtrk1 (Mus musculus)6480464CTDHDAC2 protein affects the reaction [bisphenol A results in decreased expression of NTRK1 protein]PMID:34655688
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