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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620108
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ncoa2
Name: nuclear receptor coactivator 2
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ncoa2affects bindingISONCOA2 (Homo sapiens)6480464CTD[Diethylstilbestrol binds to ESR1 protein] which binds to NCOA2 protein; [Diethylstilbestrol binds to ESR2 protein] which binds to NCOA2 proteinPMID:15123288
Ncoa2decreases expressionISONcoa2 (Mus musculus)6480464CTDDiethylstilbestrol results in decreased expression of NCOA2 proteinPMID:15019724
Ncoa2multiple interactionsISONCOA2 (Homo sapiens)6480464CTDDiethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA2 protein]; Diethylstilbestrol promotes the reaction [ESR2 protein binds to NCOA2 protein]; Diethylstilbestrol promotes the reaction [NCOA2 protein binds to ESR1 protein]PMID:10964929 PMID:15084758 PMID:32088792
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