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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620089
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ocln
Name: occludin
Acc ID: CHEBI:37941
Term: clopidogrel
Definition: A thienopyridine that is 4,5,6,7-tetrahydrothieno[3,2-c]pyridine in which the hydrogen attached to the nitrogen is replaced by an o-chlorobenzyl group, the methylene hydrogen of which is replaced by a methoxycarbonyl group (the S enantiomer). A P2Y12 receptor antagonist, it is used to inhibit blood clots and prevent heart attacks.
Chemical ID: MESH:C055162
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oclndecreases expressionISOOCLN (Homo sapiens)6480464CTDclopidogrel results in decreased expression of OCLN proteinPMID:23220562
Oclnmultiple interactionsISOOCLN (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [clopidogrel results in decreased expression of OCLN protein]PMID:23220562
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