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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620047
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il2
Name: interleukin 2
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il2decreases expressionISOIL2 (Homo sapiens)6480464CTDarsenite results in decreased expression of IL2 mRNAPMID:16085347
Il2multiple interactionsISOIL2 (Homo sapiens)6480464CTDcaffeic acid phenethyl ester inhibits the reaction [arsenite results in decreased expression of IL2 mRNA]PMID:16085347
Il2multiple interactionsISOIl2 (Mus musculus)6480464CTD[Arsenic Trioxide results in increased abundance of arsenite] which results in increased expression of IL2 proteinPMID:36791901
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