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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620039
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdx1
Name: peroxiredoxin 1
Acc ID: CHEBI:34905
Term: paraquat
Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions.
Chemical ID: MESH:D010269
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prdx1increases expressionEXP 6480464CTDParaquat results in increased expression of PRDX1 mRNAPMID:32680482
Prdx1decreases expressionISOPrdx1 (Mus musculus)6480464CTDParaquat results in decreased expression of PRDX1 mRNAPMID:17215068
Prdx1increases expressionISOPRDX1 (Homo sapiens)6480464CTDParaquat results in increased expression of PRDX1 mRNA; Paraquat results in increased expression of PRDX1 protein modified formPMID:11697128 PMID:22996356
Prdx1increases oxidationISOPRDX1 (Homo sapiens)6480464CTDParaquat results in increased oxidation of PRDX1 proteinPMID:21402726
Prdx1multiple interactionsISOPRDX1 (Homo sapiens)6480464CTD[Quercetin co-treated with Paraquat] results in increased expression of PRDX1 mRNAPMID:22996356
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