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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620039
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prdx1
Name: peroxiredoxin 1
Acc ID: CHEBI:26523
Term: reactive oxygen species
Definition: Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers.
Chemical ID: MESH:D017382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prdx1decreases abundanceISOPRDX1 (Homo sapiens)6480464CTDPRDX1 protein results in decreased abundance of Reactive Oxygen SpeciesPMID:27517622
Prdx1decreases abundanceISOPrdx1 (Mus musculus)6480464CTDPRDX1 protein results in decreased abundance of Reactive Oxygen SpeciesPMID:27517622
Prdx1multiple interactionsISOPRDX1 (Homo sapiens)6480464CTD[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species; Acetylcysteine inhibits the reaction [[frenolicin B results in decreased activity of PRDX1 protein] which results in increased abundance of Reactive Oxygen Species]PMID:30661989
Prdx1multiple interactionsISOPrdx1 (Mus musculus)6480464CTDPRDX1 protein inhibits the reaction [HRAS protein mutant form results in increased abundance of Reactive Oxygen Species]PMID:27517622
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