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GENE - TERM ANNOTATION REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfa IEP 41410819RGDmRNA, protein:increased expression:retina 
Vegfa ISOVEGFA (Homo sapiens)1580565RGD  
Vegfa ISOVEGFA (Homo sapiens)2301992RGD  
Vegfa ISOVEGFA (Homo sapiens)8547996RGDassociated with Diabetes Mellitus, type 2; protein:increased expression:aqueous humor of eyeball: 
Vegfa ISOVEGFA (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:11978667 PMID:15788408 PMID:20577866
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