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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:48080
Term: brefeldin A
Definition: A metabolite from Penicillium brefeldianum that exhibits a wide range of antibiotic activity.
Chemical ID: MESH:D020126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDBrefeldin A results in decreased secretion of VEGFA proteinPMID:12147617
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDBrefeldin A results in increased expression of VEGFA mRNAPMID:12147617
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTDBrefeldin A inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]PMID:20850416
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