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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTD[Tetradecanoylphorbol Acetate results in decreased expression of VEGFA mRNA] which results in decreased expression of PRKCE protein; Tetradecanoylphorbol Acetate results in decreased expression of VEGFA mRNAPMID:12590138
Vegfamultiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of VEGFA mRNA]; PRKCE protein affects the reaction [Tetradecanoylphorbol Acetate results in decreased expression of VEGFA mRNA]PMID:12590138
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased expression of VEGFA mRNAPMID:19910455 PMID:20438634 PMID:8537383
Vegfaincreases expressionISOVegfa (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased expression of VEGFA mRNAPMID:10788502 PMID:19000923 PMID:26513295
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased secretion of VEGFA proteinPMID:11214823
Vegfaincreases secretionISOVegfa (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased secretion of VEGFA proteinPMID:9743532
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; [ABCB1 protein results in decreased susceptibility to Doxorubicin] affects the reaction [eriodictyol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]]; [Tetradecanoylphorbol Acetate co-treated with Hydrogen Peroxide] results in increased secretion of VEGFA protein; [Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA mRNA; [Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA protein; [Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of VEGFA protein modified form; [Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of VEGFA mRNA; Acetylcysteine inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Hydrogen Peroxide] results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [[Tretinoin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of VEGFA protein]; Acetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of VEGFA protein]; eriodictyol affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; kaempferol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; Quercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [VEGFA protein results in increased expression of ACE protein]; withaferin A inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]PMID:11158990 PMID:11214823 PMID:16979875 PMID:19910455 PMID:20438634
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[Norepinephrine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of VEGFA mRNA; augustic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; corosolic acid analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; corosolic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; maslinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VEGFA mRNA]; Tetradecanoylphorbol Acetate promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA]PMID:10788502 PMID:19063610 PMID:26513295
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