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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfadecreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of VEGFA mRNAPMID:30177602
Vegfaincreases expressionEXP 6480464CTDCadmium Chloride results in increased expression of VEGFA proteinPMID:26815315
Vegfaaffects expressionISOVEGFA (Homo sapiens)6480464CTDCadmium Chloride affects the expression of VEGFA mRNAPMID:20580663
Vegfaincreases expressionISOVEGFA (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of VEGFA mRNAPMID:21984483 PMID:32512071
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of VEGFA mRNA]; U 0126 inhibits the reaction [Cadmium Chloride results in increased expression of VEGFA mRNA]PMID:21984483
Vegfamultiple interactionsISOVegfa (Mus musculus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of VEGFA mRNA; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of VEGFA protein; caffeic acid phenethyl ester inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of VEGFA protein]PMID:29373603 PMID:34791780
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