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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619991
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Vegfa
Name: vascular endothelial growth factor A
Acc ID: CHEBI:17747
Term: bis(2-ethylhexyl) phthalate
Definition: A phthalate ester that is the bis(2-ethylhexyl) ester of benzene-1,2-dicarboxylic acid.
Chemical ID: MESH:D004051
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vegfaaffects expressionEXP 6480464CTDDiethylhexyl Phthalate affects the expression of VEGFA mRNAPMID:20920545
Vegfadecreases expressionEXP 6480464CTDDiethylhexyl Phthalate results in decreased expression of VEGFA proteinPMID:36435455
Vegfadecreases expressionISOVegfa (Mus musculus)6480464CTDDiethylhexyl Phthalate results in decreased expression of VEGFA mRNAPMID:29753845
Vegfadecreases secretionISOVEGFA (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in decreased secretion of VEGFA proteinPMID:25016925
Vegfaincreases secretionISOVEGFA (Homo sapiens)6480464CTDDiethylhexyl Phthalate results in increased secretion of VEGFA proteinPMID:18252963
Vegfamultiple interactionsISOVEGFA (Homo sapiens)6480464CTDDiethylhexyl Phthalate affects the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]PMID:30851587
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