GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Vegfa | affects expression | EXP | | 6480464 | CTD | Estradiol affects the expression of VEGFA mRNA | PMID:12810170 | Vegfa | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of VEGFA mRNA | PMID:35192832 | Vegfa | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of VEGFA mRNA alternative form; Estradiol results in increased expression of VEGFA protein | PMID:36774993 PMID:8344219 PMID:9214597 | Vegfa | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with Progesterone] results in increased expression of VEGFA mRNA; [Estradiol co-treated with Progesterone] results in increased expression of VEGFA protein; [Methylnitrosourea co-treated with Estradiol] results in increased expression of VEGFA mRNA; [Methylnitrosourea co-treated with Progesterone co-treated with Estradiol] results in increased expression of VEGFA mRNA; Cycloheximide promotes the reaction [Estradiol results in increased expression of VEGFA mRNA alternative form]; Dactinomycin inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA alternative form]; Eicosapentaenoic Acid inhibits the reaction [Estradiol results in increased expression of VEGFA protein] | PMID:20732338 PMID:21277368 PMID:36774993 PMID:8344219 | Vegfa | affects expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Estradiol affects the expression of VEGFA mRNA | PMID:15598610 | Vegfa | decreases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of VEGFA mRNA | PMID:19167446 | Vegfa | decreases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Estradiol results in decreased expression of VEGFA mRNA | PMID:19693291 | Vegfa | increases expression | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of VEGFA mRNA; Estradiol results in increased expression of VEGFA protein | PMID:16299233 PMID:19148513 PMID:19828145 PMID:19838210 PMID:27856279 PMID:30328349 PMID:31614463 PMID:31646340 PMID:33728745 | Vegfa | increases expression | ISO | Vegfa (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of VEGFA mRNA; Estradiol results in increased expression of VEGFA protein | PMID:15591033 PMID:17640349 PMID:20025956 PMID:25210133 | Vegfa | increases secretion | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | Estradiol results in increased secretion of VEGFA protein | PMID:17289903 PMID:18252963 PMID:19828145 | Vegfa | multiple interactions | ISO | VEGFA (Homo sapiens) | 6480464 | CTD | 2,3-bis(3'-hydroxybenzyl)butane-1,4-diol inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; 2,3-bis(3'-hydroxybenzyl)butyrolactone inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; [Estradiol co-treated with EGF protein] results in increased expression of VEGFA mRNA; [Estradiol results in increased secretion of VEGFA protein] which results in increased expression of KDR protein; afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; afimoxifene inhibits the reaction [Estradiol results in increased expression of VEGFA protein]; Estradiol promotes the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of VEGFA mRNA]; Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of VEGFA protein]; SB 203580 inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Estradiol results in increased secretion of VEGFA protein] | PMID:17289903 PMID:18252963 PMID:19148513 PMID:24758408 PMID:30851587 PMID:31646340 | Vegfa | multiple interactions | ISO | Vegfa (Mus musculus) | 6480464 | CTD | [Estradiol co-treated with Progesterone] results in decreased expression of VEGFA mRNA; [Estradiol co-treated with Progesterone] results in increased expression of VEGFA mRNA; Estradiol affects the reaction [CYP19A1 affects the expression of VEGFA mRNA] | PMID:11985600 PMID:19693291 | | ||||||||||||||||||||||
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